A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation
نویسندگان
چکیده
منابع مشابه
A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation
Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, human bi-functional antibody-receptor domain fusion molecule with ligand capture (bi-AbCap) through the fusion of the domain 2 of human vascular endoth...
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متن کاملInhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody.
Insulin-like growth factor-I receptor (IGF-IR) plays an important role in tumor cell growth and survival. On ligand stimulation, IGF-IR, a receptor tyrosine kinase, phosphorylates tyrosine residues on two major substrates, IRS-1 and Shc, which subsequently signal through the Ras/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/AKT pathways. Here, we describe the characterizati...
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ژورنال
عنوان ژورنال: mAbs
سال: 2015
ISSN: 1942-0862,1942-0870
DOI: 10.1080/19420862.2015.1055442